Unknown,Transcriptomics,Genomics,Proteomics

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Bulk RNA-seq of of human dermal fibroblasts from up to 66 individuals (supplementary)

ABSTRACT: Dermal fibroblasts from up to 66 human donors, stimulated with dsRNA (poly I:C) in a time course of 0, 2, 6 hours, profiled using the Smart-seq2 protocol. Donor fibroblast samples were supplied by the Hipsci consortium.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Homo sapiens

SUBMITTER: Tzachi Hagai 

PROVIDER: E-MTAB-7032 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

As the first line of defence against pathogens, cells mount an innate immune response, which varies widely from cell to cell. The response must be potent but carefully controlled to avoid self-damage. How these constraints have shaped the evolution of innate immunity remains poorly understood. Here we characterize the innate immune response's transcriptional divergence between species and variability in expression among cells. Using bulk and single-cell transcriptomics in fibroblasts and mononuc  ...[more]

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