Methylation arrays (MethylationEPIC) of longitudinal cord and peripheral blood from children aged 0, 5 and 10 years old

ABSTRACT: Extensive epigenetic remodelling takes place during early life; however, the alterations of DNA methylation that occur during this period have not been sufficiently addressed by longitudinal studies. We made use of the most recent Illumina MethylationEPIC Beadchip platform to characterize genome-wide DNA methylation changes observed through the first 10 years of life in longitudinal blood samples of 11 subjects. We described numerous changes during the first 5 years, while many less alterations in the following 5 year period. Interestingly, we identified a subset of persistent DNA methylation changes of considerable magnitude along the first 10 years of life. Moreover, our data demonstrated that genes that suffer simultaneous hyper- and hypomethylation are functionally different from genes

ORGANISM(S): Homo sapiens

SUBMITTER: Mario Fraga F. 

PROVIDER: E-MTAB-7069 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress