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Methylation arrays (MethylationEPIC) of whole blood of individuals with type 1 diabetes

ABSTRACT: Type 1 diabetes (1a) diabetes is an autoimmune disease in which both environmental and genetic factors play a role. Epigenetic marks such as DNA methylation, being molecular links between the environment and the genome function, are sound candidates for the explanation of part of the aetiology and mechanisms of the disease. Here, the methylomes of the whole blood of 18 adult individuals with T1D were profiled using Illumina's MethylationEPIC array technology.

ORGANISM(S): Homo sapiens

SUBMITTER: Mario Fraga F.

PROVIDER: E-MTAB-8694 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Methylation arrays (MethylationEPIC) of longitudinal cord and peripheral blood from children aged 0, 5 and 10 years old

Project description:Extensive epigenetic remodelling takes place during early life; however, the alterations of DNA methylation that occur during this period have not been sufficiently addressed by longitudinal studies. We made use of the most recent Illumina MethylationEPIC Beadchip platform to characterize genome-wide DNA methylation changes observed through the first 10 years of life in longitudinal blood samples of 11 subjects. We described numerous changes during the first 5 years, while many less alterations in the following 5 year period. Interestingly, we identified a subset of persistent DNA methylation changes of considerable magnitude along the first 10 years of life. Moreover, our data demonstrated that genes that suffer simultaneous hyper- and hypomethylation are functionally different from genes that are exclusively hyper- or hypomethylated. Furthermore, our results evidence that enhancer-associated methylation changes are different for the gain or loss of methylation. throughout hematopoietic maturation by analyzing multiple hematopoietic cell types at different developmental stages. We identified a plethora of DNA methylation changes that occur during human hematopoietic differentiation. Interestingly, we observed that T lymphocytes display a substantial enhancement of de novo CpG hypermethylation as compared to other hematopoietic cell populations.

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