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Unknown,Transcriptomics,Genomics,Proteomics

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Gene expression regulated by miR-101 in murine MLL-AF9-transduced LSK cells

ABSTRACT: miR-101 has been reported as a tumor suppressor in several types of cancer. However, its role in AML is still unknown. In this study, we restored the expression of miR-101 in MLL-AF9 transduced LSK cells by introducing a retroviral miR-101 expression vector. To identify miR-101-regulated gene expression, we performed genome-wide gene expression analysis on GFP+ MLL-AF9-transduced LSK cells overexpressing miR-101 versus control vector. Our gene expression analysis and subsequent functional studies demonstrate that enforced expression of miR-101 has antitumor effects on the development of MLL-rearranged AML. Each group has 3 samples.

ORGANISM(S): Mus musculus

SUBMITTER: Jenny Wang

PROVIDER: E-MTAB-7344 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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