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Gene mRNA levels in the bone of FAM20C KO mice VS WT mice (3-WK-old)

ABSTRACT: Family with sequence similarity 20-member C (FAM20C) is a new molecule that is highly expressed in the mineralized tissues of mammals. Genetic studies showed that the loss-of-function mutations in FAM20C were associated with human lethal osteosclerotic bone dysplasia (Raine Syndrome), indicating that this molecule may act as an inhibitor in the formation of bone. However, the in vitro gain- and loss-of-function studies suggested that FAM20C promoted the differentiation and mineralization of mouse mesenchymal cells and odontoblasts. To study the roles of FAM20C, we generated Fam20C conditional knockout (cKO) mice in which Fam20C was ubiquitously inactivated. Microarray analyses were performed using total RNA extracted from the calvaria of 3-week-old mice.

ORGANISM(S): Mus musculus

SUBMITTER: Xiaofang Wang

PROVIDER: E-MTAB-772 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice.

Wang Xiaofang X Wang Suzhen S Li Changcheng C Gao Tian T Liu Ying Y Rangiani Afsaneh A Sun Yao Y Hao Jianjun J George Anne A Lu Yongbo Y Groppe Jay J Yuan Baozhi B Feng Jian Q JQ Qin Chunlin C

PLoS genetics 20120517 5

Family with sequence similarity 20,-member C (FAM20C) is highly expressed in the mineralized tissues of mammals. Genetic studies showed that the loss-of-function mutations in FAM20C were associated with human lethal osteosclerotic bone dysplasia (Raine Syndrome), implying an inhibitory role of this molecule in bone formation. However, in vitro gain- and loss-of-function studies suggested that FAM20C promotes the differentiation and mineralization of mouse mesenchymal cells and odontoblasts. Rece ...[more]

PMID: 22615579

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