Transcriptional profiling by array in rat of age-dependent gene expression in sensorimotor cortex following spinal cord injury
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ABSTRACT: In this study, we investigated the extent and nature of the difference between the dynamic cortical gene expression profiles of aged (22-month-old) and young (2-month-old) rats following thoracic corticospinal tract (CST) transection and whether the anti-scarring-treatment (AST)-induced regeneration program can be activated in aged animals. GeneChip analysis was performed on layers V/VI of the rat sensorimotor cortex at 1, 7 and 35 days post operation (dpo), which represented the acute, subacute and chronic stages of SCI, respectively. Anti-scarring treatment (AST) includes local injections of an iron chelator and cAMP immediately after SCI. For our purpose we used the Affymetrix GeneChip Rat Gene 1.0 ST Array (A-AFFY-160) which contains approximately 27,000 genes.
ORGANISM(S): Rattus norvegicus
SUBMITTER: Anne Jaerve
PROVIDER: E-MTAB-794 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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