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Transcriptional profiling in microglia and peripheral macrophages phenotypes during development and neuroinflammation in mouse

ABSTRACT: Understanding the respective role of microglia and infiltrating monocytes in neuroinflammatory conditions has recently seemed possible by the identification of a specific microglia signature. Here instead we provide evidence that peripheral macrophages may express some of the most commonly described microglia markers at some developmental stages or pathological conditions, in particular during chronic neuroinflammation. Further, our data support the hypothesis about phenotypic plasticity and convergence among distinct myeloid cells so that they may act as a functional unit rather than as different entities, boosting their mutual functions in different phases of disease. This holds relevant implications in the view of the growing use of myeloid cell therapies to treat brain disease in humans.

ORGANISM(S): Mus musculus

SUBMITTER: Ramesh Menon

PROVIDER: E-MTAB-8059 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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