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Effect of c-Myb knockdown on global gene expression

ABSTRACT: Effect of c-Myb knockdown in K562 on global gene expression after knockdown using siRNA oligo si323 or si2992.

ORGANISM(S): Homo sapiens

SUBMITTER: Elen Margrethe Brendeford

PROVIDER: E-MTAB-807 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of c-Myb Target Genes in K562 Cells Reveals a Role for c-Myb as a Master Regulator.

Lorenzo Petra Isabel PI Brendeford Elen Margrethe EM Gilfillan Siv S Gavrilov Alexey A AA Leedsak Marit M Razin Sergey V SV Eskeland Ragnhild R Sæther Thomas T Gabrielsen Odd Stokke OS

Genes & cancer 20110801 8

The c-Myb transcription factor is an important regulator of hematopoietic cell development. c-Myb is expressed in immature hematopoietic cells and plays a direct role in lineage fate selection, cell cycle progression, and differentiation of myeloid as well as B- and T-lymphoid progenitor cells. As a DNA-binding transcription factor, c-Myb regulates specific gene programs through activation of target genes. Still, our understanding of these programs is incomplete. Here, we report a set of novel c ...[more]

PMID: 22393465

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