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ATAC-seq of oesophageal adenocarcinoma patient samples

ABSTRACT: Open chromatin profiling (ATAC-seq) of human oesophageal adenocarcinoma patient samples.

INSTRUMENT(S): Illumina HiSeq 4000

ORGANISM(S): Homo sapiens

SUBMITTER: Connor Rogerson

PROVIDER: E-MTAB-8447 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of a primitive intestinal transcription factor network shared between esophageal adenocarcinoma and its precancerous precursor state.

Rogerson Connor C Britton Edward E Withey Sarah S Hanley Neil N Ang Yeng S YS Sharrocks Andrew D AD

Genome research 20190408 5

Esophageal adenocarcinoma (EAC) is one of the most frequent causes of cancer death, and yet compared to other common cancers, we know relatively little about the molecular composition of this tumor type. To further our understanding of this cancer, we have used open chromatin profiling to decipher the transcriptional regulatory networks that are operational in EAC. We have uncovered a transcription factor network that is usually found in primitive intestinal cells during embryonic development, c ...[more]

PMID: 30962179

Publication: 1/2

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