Unknown,Transcriptomics,Genomics,Proteomics

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Transcriptional profiling by array of human head and neck squamous cell carcinoma to study the correlation between galectin-1 upregulation and the presence of SMA positive cancer-associated fibroblasts


ABSTRACT: In this study, we set the presence of smooth muscle actin (SMA)-positive cancer-associated fibroblasts (CAFs) in relation to galectin-1 and its in vivo competitor (galectin-3). In squamous cell carcinomas of head and neck, upregulation of galectin-1 presence is highly significantly correlated to presence of smooth muscle actin-positive cancer-associated fibroblasts in the tumor. In order to pinpoint correlations on the molecular level, we applied microarray analyses to the transcription profiles of the corresponding tumors. Significant correlations of several transcripts were detected with the protein level of galectin-1 in the cancer-associated fibroblasts.

ORGANISM(S): Homo sapiens

DISEASE(S): tumour

SUBMITTER: Michal Kolar 

PROVIDER: E-MTAB-850 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Smooth muscle actin-expressing stromal fibroblasts in head and neck squamous cell carcinoma: increased expression of galectin-1 and induction of poor prognosis factors.

Valach Jaroslav J   Fík Zdeněk Z   Strnad Hynek H   Chovanec Martin M   Plzák Jan J   Cada Zdeněk Z   Szabo Pavol P   Sáchová Jana J   Hroudová Miluše M   Urbanová Markéta M   Steffl Martin M   Pačes Jan J   Mazánek Jiří J   Vlček Cestmír C   Betka Jan J   Kaltner Herbert H   André Sabine S   Gabius Hans-Joachim HJ   Kodet Roman R   Smetana Karel K   Gál Peter P   Kolář Michal M  

International journal of cancer 20120409 11


Tumor stroma is an active part influencing the biological properties of malignancies via molecular cross-talk. Cancer-associated fibroblasts play a significant role in this interaction. These cells frequently express smooth muscle actin and can be classified as myofibroblasts. The adhesion/growth-regulatory lectin galectin-1 is an effector for their generation. In our study, we set the presence of smooth muscle actin-positive cancer-associated fibroblasts in relation to this endogenous lectin an  ...[more]

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