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Single nucleus RNA sequencing of human deep neck BAT

ABSTRACT: single-nucleus RNA sequencing is applied on human brown adipose tissue at deep neck.

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: Wenfei Sun

PROVIDER: E-MTAB-8564 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis.

Sun Wenfei W Dong Hua H Balaz Miroslav M Slyper Michal M Drokhlyansky Eugene E Colleluori Georgia G Giordano Antonio A Kovanicova Zuzana Z Stefanicka Patrik P Balazova Lucia L Ding Lianggong L Husted Anna Sofie AS Rudofsky Gottfried G Ukropec Jozef J Cinti Saverio S Schwartz Thue W TW Regev Aviv A Wolfrum Christian C

Nature 20201028 7832

Adipose tissue is usually classified on the basis of its function as white, brown or beige (brite)1. It is an important regulator of systemic metabolism, as shown by the fact that dysfunctional adipose tissue in obesity leads to a variety of secondary metabolic complications2,3. In addition, adipose tissue functions as a signalling hub that regulates systemic metabolism through paracrine and endocrine signals4. Here we use single-nucleus RNA-sequencing (snRNA-seq ...[more]

PMID: 33116305

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