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Comparison of the effects of curcumin on rat neonate lungs in control animals and rats affected by Intra-Uterine Growth restriction following Low Protein Diet of the mothers (LPD Model)

ABSTRACT: Neonates born pre-term or/and at low weight often suffer from defective lung function where PPAR-gamma cascades play an important role. Curcumin is a PPAR gamma agonist

ORGANISM(S): Rattus norvegicus

SUBMITTER: Daniel Vaiman

PROVIDER: E-MTAB-8719 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Impaired alveolarization and intra-uterine growth restriction in rats: a postnatal genome-wide analysis.

Zana-Taieb E E Pham H H Franco-Montoya M L ML Jacques S S Letourneur F F Baud O O Jarreau P H PH Vaiman D D

The Journal of pathology 20150201 3

Intra-uterine growth restriction (IUGR) dramatically increases the risk of bronchopulmonary dysplasia in preterm babies, a disease characterized by arrested alveolarization and abnormal microvascular angiogenesis. We have previously described a rodent low protein diet (LPD) model of IUGR inducing impaired alveolarization, but failed to demonstrate any modification of the classical factors involved in lung development. We performed a genome-wide microarray analysis in 120 rat pups with LPD-induce ...[more]

PMID: 25347958

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Comparison of the effects of curcumin on rat neonate lungs in control animals and rats affected by Intra-Uterine Growth restriction following Low Protein Diet of the mothers (LPD Model) at postnatal day 11

Project description:Neonates born pre-term or/and at low weight often suffer from defective lung function where PPAR-gamma cascades play an important role. Curcumin is a PPAR gamma agonist at postnatal day 11

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