Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Daniel Vaiman
PROVIDER: E-MTAB-1970 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Antioxidants & redox signaling 20140620 6
<h4>Aims</h4>Storkhead box 1 (STOX1) is a winged-helix transcription factor that is implicated in the genetic forms of a high-prevalence human gestational disease, pre-eclampsia. STOX1 overexpression confers pre-eclampsia-like transcriptomic features to trophoblastic cell lines and pre-eclampsia symptoms to pregnant mice. The aim of this work was to evaluate the impact of STOX1 on free radical equilibrium and mitochondrial function, both in vitro and in vivo.<h4>Results</h4>Transcriptome analysi ...[more]