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Cytotoxic and anti-Toxoplasma gondii activities of monensin on human brain microvascular endothelial cells

ABSTRACT: The aim of the present work was to investigate the effect of monensin on the in vitro growth of T. gondii tachyzoites and on the host cells (human brain microvascular endothelial cells - hBMECs). The hypotheses were that (1) inhibition of the WNT signalling pathway by monensin can reduce the growth of T. gondii infecting human brain microvascular endothelial cells (hBMECs) and (2) by suppression of the growth of T. gondii using monensin, impairment of the BBB integrity can be restored (3) inhibition of WNT pathway by monensin can be detected by microarray experiment.

ORGANISM(S): Homo sapiens

SUBMITTER: Mohammad Syamsul Reza Harun

PROVIDER: E-MTAB-8817 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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