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Proteogenomic analysis of Toxoplasma gondii (comparing genome releases 6 and 10) to demonstrate the performance of the ProteoAnnotator software

ABSTRACT: Testing the performance of the ProteoAnnotator software via comparing analysis of annotating the Toxoplasma gondii gene models 6 and 10

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Toxoplasma Gondii Me49

SUBMITTER: Fawaz Ghali

LAB HEAD: Andrew R. Jones

PROVIDER: PXD001042 | Pride | 2014-10-20

REPOSITORIES: Pride

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ProteoAnnotator--open source proteogenomics annotation software supporting PSI standards.

Ghali Fawaz F Krishna Ritesh R Perkins Simon S Collins Andrew A Xia Dong D Wastling Jonathan J Jones Andrew R AR

Proteomics 20141119 23-24

The recent massive increase in capability for sequencing genomes is producing enormous advances in our understanding of biological systems. However, there is a bottleneck in genome annotation--determining the structure of all transcribed genes. Experimental data from MS studies can play a major role in confirming and correcting gene structure--proteogenomics. However, there are some technical and practical challenges to overcome, since proteogenomics requires pipelines comprising a complex set o ...[more]

PMID: 25297486

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