Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Carmody Leigh
PROVIDER: E-MTAB-884 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Carmody Leigh C LC Germain Andrew R AR VerPlank Lynn L Nag Partha P PP Muñoz Benito B Perez Jose R JR Palmer Michelle A J MA
Journal of biomolecular screening 20120830 9
Cancer stem cells (CSCs) are resistant to standard cancer treatments and are likely responsible for cancer recurrence, but few therapies target this subpopulation. Due to the difficulty in propagating CSCs outside of the tumor environment, previous work identified CSC-like cells by inducing human breast epithelial cells into an epithelial-to-mesenchymal transdifferentiated state (HMLE_sh_ECad). A phenotypic screen was conducted against HMLE_sh_ECad with 300 718 compounds from the Molecular Libra ...[more]