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Pinschewer_Kallert_1210

ABSTRACT: We had 2 groups of 3 mice each. One group we infected with 200 pfu lymphocytic choriomeningitis virus-strain WE (LCMV-WE) and the other group stays uninfected. 5 days post infection we take the spleen, extract total RNA and then the microarray was performed.

ORGANISM(S): Mus musculus

SUBMITTER: Sandra Kallert

PROVIDER: E-MTAB-901 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The alarmin interleukin-33 drives protective antiviral CD8⁺ T cell responses.

Bonilla Weldy V WV Fröhlich Anja A Senn Karin K Kallert Sandra S Fernandez Marylise M Johnson Susan S Kreutzfeldt Mario M Hegazy Ahmed N AN Schrick Christina C Fallon Padraic G PG Klemenz Roman R Nakae Susumu S Adler Heiko H Merkler Doron D Löhning Max M Pinschewer Daniel D DD

Science (New York, N.Y.) 20120209 6071

Pathogen-associated molecular patterns decisively influence antiviral immune responses, whereas the contribution of endogenous signals of tissue damage, also known as damage-associated molecular patterns or alarmins, remains ill defined. We show that interleukin-33 (IL-33), an alarmin released from necrotic cells, is necessary for potent CD8(+) T cell (CTL) responses to replicating, prototypic RNA and DNA viruses in mice. IL-33 signaled through its receptor on activated CTLs, enhanced clonal exp ...[more]

PMID: 22323740

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