Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of wild type and Sox9 knock out mice to study the role of Sox 9 (testis determining gene) after testis induction

ABSTRACT: To study the role of the testis determining gene Sox9 after testis induction, conditional inactivation of Sox9 was achieved with the help of an AMH-Cre line. Mutant mice are fertile up to about 3 months of age, becoming sterile afterwards. Expression profiles should help to reveal the underlying cause.

ORGANISM(S): Mus musculus

SUBMITTER: Philippe Demougin 

PROVIDER: E-TABM-528 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Profiling spermatogenic failure in adult testes bearing Sox9-deficient Sertoli cells identifies genes involved in feminization, inflammation and stress.

Lardenois Aurélie A   Chalmel Frédéric F   Barrionuevo Francisco F   Demougin Philippe P   Scherer Gerd G   Primig Michael M  

Reproductive biology and endocrinology : RB&E 20101223

<h4>Background</h4>Sox9 (Sry box containing gene 9) is a DNA-binding transcription factor involved in chondrocyte development and sex determination. The protein's absence in testicular Sertoli nurse cells has been shown to disrupt testicular function in adults but little is known at the genome-wide level about molecular events concomitant with testicular break-down.<h4>Methods</h4>To determine the genome-wide effect on mRNA concentrations triggered by the absence of Sox9 in Sertoli cells we anal  ...[more]

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