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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human testis samples from men with highly defined and homogenous testicular pathologies reveals patterns that correlate with distinct stages of spermatogenesis

ABSTRACT: Identification of gene expression patterns that correlate with distinct stages of male germ cell development using biopsies from men with highly defined and homogenous testicular pathologies based on the Johnsen score procedure. The Johnsen score procedure is a classical histopathological scoring procedure that classifies the germ cell composition from different stages of spermatogenic impairment.

ORGANISM(S): Homo sapiens

SUBMITTER: Caroline Feig

PROVIDER: E-TABM-234 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Cross-platform gene expression signature of human spermatogenic failure reveals inflammatory-like response.

Spiess Andrej-Nikolai AN Feig Caroline C Schulze Wolfgang W Chalmel Frédéric F Cappallo-Obermann Heike H Primig Michael M Kirchhoff Christiane C

Human reproduction (Oxford, England) 20071006 11

<h4>Background</h4>The molecular basis of human testicular dysfunction is largely unknown. Global gene expression profiling of testicular biopsies might reveal an expression signature of spermatogenic failure in azoospermic men.<h4>Methods</h4>Sixty-nine individual testicular biopsy samples were analysed on two microarray platforms; selected genes were validated by quantitative real-time PCR and immunohistochemistry.<h4>Results</h4>A minimum of 188 transcripts were significantly increased on bot ...[more]

PMID: 17921478

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