Dataset Information
3’-Seq of multipotent progenitor cells MPP5
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2000
ORGANISM(S): Mus musculus
SUBMITTER: Pia Sommerkamp
PROVIDER: E-MTAB-9135 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Mouse multipotent progenitor 5 cells are located at the interphase between hematopoietic stem and progenitor cells.
Blood 20210601 23
Hematopoietic stem cells (HSCs) and distinct multipotent progenitor (MPP) populations (MPP1-4) contained within the Lin-Sca-1+c-Kit+ (LSK) compartment have previously been identified using diverse surface-marker panels. Here, we phenotypically define and functionally characterize MPP5 (LSK CD34+CD135-CD48-CD150-). Upon transplantation, MPP5 supports initial emergency myelopoiesis followed by stable contribution to the lymphoid lineage. MPP5, capable of generating MPP1-4 but not HSCs, represents ...[more]
