Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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ATAC-seq of mouse embryonic stem cells


ABSTRACT: To identify the accessible chromatin in wild-type mouse embryonic stem cells (mESCs), we performed ATAC-seq in mESCs.

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Mus musculus

SUBMITTER: Shaun Webb 

PROVIDER: E-MTAB-9245 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Mammalian genomes contain long domains with distinct average compositions of A/T versus G/C base pairs. In a screen for proteins that might interpret base composition by binding to AT-rich motifs, we identified the stem cell factor SALL4, which contains multiple zinc fingers. Mutation of the domain responsible for AT binding drastically reduced SALL4 genome occupancy and prematurely upregulated genes in proportion to their AT content. Inactivation of this single AT-binding zinc-finger cluster mi  ...[more]

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