Unknown,Transcriptomics,Genomics,Proteomics

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Menstrual flow as a non-invasive source of endometrial organoids


ABSTRACT: Organoid cultures derived from menstrual flow faithfully replicate secretory phase endometrial glands and provide a novel, non-invasive technique for the clinical assessment of endometrial function. Paired organoid cultures derived from scratch biopsies and ensuing menstrual flow share the same transcriptome signature, responses to early pregnancy hormones, and pathological changes in cases of early-pregnancy loss. The technique opens new avenues for investigating endometrial function in cases of subfertility and gynaecological disorders.

INSTRUMENT(S): NextSeq 500

ORGANISM(S): Homo sapiens

SUBMITTER: Xiaohui Zhao 

PROVIDER: E-MTAB-9284 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Menstrual flow as a non-invasive source of endometrial organoids.

Cindrova-Davies Tereza T   Zhao Xiaohui X   Elder Kay K   Jones Carolyn J P CJP   Moffett Ashley A   Burton Graham J GJ   Turco Margherita Y MY  

Communications biology 20210617 1


Assessment of the endometrium often necessitates a biopsy, which currently involves an invasive, transcervical procedure. Here, we present an alternative technique based on deriving organoids from menstrual flow. We demonstrate that organoids can be derived from gland fragments recovered from menstrual flow. To confirm they faithfully reflect the in vivo state we compared organoids derived from paired scratch biopsies and ensuing menstrual flow from patients undergoing in vitro fertilisation (IV  ...[more]

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