Unknown,Transcriptomics,Genomics,Proteomics

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PAO1-1037


ABSTRACT: Gene expression in biofilms of PAO1 with and without the presence of 20 ug/ml peptide 1037 was analysed using microarrays.

ORGANISM(S): Pseudomonas aeruginosa

SUBMITTER: Karsten Hokamp 

PROVIDER: E-MTAB-962 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Inhibition of bacterial biofilm formation and swarming motility by a small synthetic cationic peptide.

de la Fuente-Núñez César C   Korolik Victoria V   Bains Manjeet M   Nguyen Uyen U   Breidenstein Elena B M EB   Horsman Shawn S   Lewenza Shawn S   Burrows Lori L   Hancock Robert E W RE  

Antimicrobial agents and chemotherapy 20120221 5


Biofilms cause up to 80% of infections and are difficult to treat due to their substantial multidrug resistance compared to their planktonic counterparts. Based on the observation that human peptide LL-37 is able to block biofilm formation at concentrations below its MIC, we screened for small peptides with antibiofilm activity and identified novel synthetic cationic peptide 1037 of only 9 amino acids in length. Peptide 1037 had very weak antimicrobial activity, but at 1/30th the MIC the peptide  ...[more]

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