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DNA methylation in oesophageal biopsies of children diagnosed with Eosinophilic Oesophagitis (EoE) and controls

ABSTRACT: Eosinophilic oesophagitis (EoE) is a leading cause of dysphagia and food impaction in children and adults. In this pilot study, we performed genome-wide DNA methylation analyses on oesophageal biopsies obtained from children diagnosed with EoE (at diagnosis and after treatment) and matched controls. Analyses reveal striking disease associated differences in the DNA methylation profile of mucosal biopsies in children diagnosed with EoE, highlighting the great potential for epigenetic signatures to be developed into clinically applicable biomarkers.

ORGANISM(S): Homo sapiens

SUBMITTER: Matthias Zilbauer

PROVIDER: E-MTAB-9824 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Disease-associated DNA methylation signatures in esophageal biopsies of children diagnosed with Eosinophilic Esophagitis.

Strisciuglio Caterina C Payne Felicity F Nayak Komal K Andreozzi Marialuisa M Vitale Alessandra A Miele Erasmo E Zilbauer Matthias M

Clinical epigenetics 20210417 1

Eosinophilic esophagitis (EoE) is a leading cause of dysphagia and food impaction in children and adults. The diagnosis relies on histological examination of esophageal mucosal biopsies and requires the presence of > 15 eosinophils per high-powered field. Potential pitfalls include the impact of biopsy sectioning as well as regional variations of eosinophil density. We performed genome-wide DNA methylation analyses on 30 esophageal biopsies obtained from children diagnosed with EoE (n = 7) and m ...[more]

PMID: 33865442

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