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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human BRAFE600-induced senescent, senescence bypassing, and quiescent fibroblast cells, compared to cycling cells

ABSTRACT: Analysis of BRAFE600-induced senescent, senescence bypassing, and quiescent cells, all compared to cycling cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Thomas Kuilman

PROVIDER: E-NCMF-12 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network.

Kuilman Thomas T Michaloglou Chrysiis C Vredeveld Liesbeth C W LC Douma Sirith S van Doorn Remco R Desmet Christophe J CJ Aarden Lucien A LA Mooi Wolter J WJ Peeper Daniel S DS

Cell 20080601 6

Oncogene-induced cellular senescence (OIS) is emerging as a potent cancer-protective response to oncogenic events, serving to eliminate early neoplastic cells from the proliferative pool. Using combined genetic and bioinformatic analysis, we find that OIS is linked specifically to the activation of an inflammatory transcriptome. Induced genes included the pleiotropic cytokine interleukin-6 (IL-6), which upon secretion by senescent cells acted mitogenically in a paracrine fashion. Unexpectedly, I ...[more]

PMID: 18555778

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Project description:97 triple negative tumors were selected from the fresh-frozen tissue bank of the Netherlands Cancer Institute and gene expression profiles were generated using 35K oligonucleotide microarrays. Human breast carcinomas were snap frozen in liquid nitrogen within one hour after surgery and stored in the fresh-frozen tissue bank of the Netherlands Cancer Institute. RNA from a pool of more than 100 unselected fresh frozen breast carcinomas were isolated and pooled to form the reference to which each individual breast carcinoma is hybridized.

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Dosage dependent tumor suppression by histone deacetylases 1/2

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