Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human BRAFE600-induced senescent, senescence bypassing, and quiescent fibroblast cells, compared to cycling cells


ABSTRACT: Analysis of BRAFE600-induced senescent, senescence bypassing, and quiescent cells, all compared to cycling cells.

ORGANISM(S): Homo sapiens

SUBMITTER: Thomas Kuilman 

PROVIDER: E-NCMF-12 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Oncogene-induced cellular senescence (OIS) is emerging as a potent cancer-protective response to oncogenic events, serving to eliminate early neoplastic cells from the proliferative pool. Using combined genetic and bioinformatic analysis, we find that OIS is linked specifically to the activation of an inflammatory transcriptome. Induced genes included the pleiotropic cytokine interleukin-6 (IL-6), which upon secretion by senescent cells acted mitogenically in a paracrine fashion. Unexpectedly, I  ...[more]

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