Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Thomas Kuilman
PROVIDER: E-NCMF-12 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cell 20080601 6
Oncogene-induced cellular senescence (OIS) is emerging as a potent cancer-protective response to oncogenic events, serving to eliminate early neoplastic cells from the proliferative pool. Using combined genetic and bioinformatic analysis, we find that OIS is linked specifically to the activation of an inflammatory transcriptome. Induced genes included the pleiotropic cytokine interleukin-6 (IL-6), which upon secretion by senescent cells acted mitogenically in a paracrine fashion. Unexpectedly, I ...[more]