Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcription profiling of liver and small intestine from Cyp3a/Mdr1a/1b knock-out mice and wild-type mice

ABSTRACT: comparison Cyp3a/Mdr1a/1b ko mice with wild-type mice (both FVB background)

ORGANISM(S): Mus musculus

SUBMITTER: Robert van Waterschoot

PROVIDER: E-NCMF-26 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Publications

Absence of both cytochrome P450 3A and P-glycoprotein dramatically increases docetaxel oral bioavailability and risk of intestinal toxicity.

van Waterschoot Robert A B RA Lagas Jurjen S JS Wagenaar Els E van der Kruijssen Cornelia M M CM van Herwaarden Antonius E AE Song Ji-Ying JY Rooswinkel Rogier W RW van Tellingen Olaf O Rosing Hilde H Beijnen Jos H JH Schinkel Alfred H AH

Cancer research 20091117 23

Docetaxel is one of the most widely used anticancer drugs. A major problem with docetaxel treatment, however, is the considerable interpatient variability in docetaxel exposure. Another disadvantage of the drug is that it has a very low oral bioavailability and can therefore only be administered i.v. The drug-metabolizing enzyme cytochrome P450 3A (CYP3A) and the drug transporter P-glycoprotein (P-gp; MDR1) are considered to be major determinants of docetaxel pharmacokinetics. It has been hypoth ...[more]

PMID: 19920203

Similar Datasets

Transcription profiling of human breast carcinomas negative for estrogen, progesterone and HER2/nue receptors

Project description:97 triple negative tumors were selected from the fresh-frozen tissue bank of the Netherlands Cancer Institute and gene expression profiles were generated using 35K oligonucleotide microarrays. Human breast carcinomas were snap frozen in liquid nitrogen within one hour after surgery and stored in the fresh-frozen tissue bank of the Netherlands Cancer Institute. RNA from a pool of more than 100 unselected fresh frozen breast carcinomas were isolated and pooled to form the reference to which each individual breast carcinoma is hybridized.

2007-10-09 | E-NCMF-2 | biostudies-arrayexpress

Transcription profiling of 165 human primary breast carcinomas and 15 recurred tumors to investigate expression profiles in relation to the risk of developing local recurrence after breast conserving therapy

Project description:165 primary breast carcinomas were selected to study the gene expression profile in relation to the risk of developping local recurrence after breast conserving therapy; in addition 15 recurred tumors were profiled for comparison to their primary tumor.

2009-04-01 | E-NCMF-24 | biostudies-arrayexpress

Transcription profiling of human CD34+CD38- and CD34+CD38+ cells from patients with acute myelogenous leukemia (AML)

Project description: Not available

2008-08-01 | E-NCMF-11 | biostudies-arrayexpress

Transcription profiling of human invasive breast cancer carcinomas with different histological types and invasive lobular carcinoma

Project description:Gene expression array analysis on a series of ten different histological special types of invasive breast carcinomas (tubular, micropapillary, mucinous A, mucinous B, endocrine, apocrine, metaplastic, medullary, adenoid cystic, invasive ductal carcinoma with osteoclastic giant cells) and invasive lobular carcinoma.<br><br>Note: this experiment was reloaded into ArrayExpress in August 2010 to include mappings between raw and processed data files. It now includes additional dye-swap combined normalized data files.

2010-08-20 | E-NCMF-3 | biostudies-arrayexpress

Dosage dependent tumor suppression by histone deacetylases 1/2

Project description:Dosage dependent tumor suppression by histone deacetylases 1/2

2013-03-21 | E-MTAB-1448 | biostudies-arrayexpress

Transcription profiling by array of mouse small cell lung cancer tumor samples

Project description:Expressionarray data for A functional role for tumor cell heterogeneity in a mouse model of Small Cell Lung Cancer

2011-02-19 | E-NCMF-37 | biostudies-arrayexpress

Transcription profiling and detection of in vivo protein-DNA interactions in a Burkitts lymphoma cell line using DamID methodology

Project description:-

2009-02-06 | E-NCMF-15 | biostudies-arrayexpress

Transcription profiling of mouse embryonic fibroblast-TBX2 cells treated with LPA or EGF

Project description:EXPERIMENT 3: LPA compared to EGF response; LPA concentration 5uM; EGF concentration 50ng/ml

2009-02-14 | E-NCMF-18 | biostudies-arrayexpress

Transcription profiling of untreated and cisplatin-based chemoradiation treated human squamous cell carcinomas to improve prediction of outcome after chemoradiation

Project description:Gene expression profiling to predict outcome after chemoradiation in head and neck cancer Purpose. The goal of the present study was to improve prediction of outcome after chemoradiation in advanced head and neck cancer using gene expression analysis. Materials and Methods. We collected 92 biopsies from untreated head and neck cancer patients subsequently given cisplatin-based chemoradiation (RADPLAT) for advanced squamous cell carcinomas (HNSCC). After RNA extraction and labeling we performed dye swap experiments using 35k oligo-microarrays. Supervised analyses were performed to create classifiers to predict local control, locoregional control and disease recurrence. Published gene sets with prognostic value in other studies were also tested. Results. Using supervised classification on the whole series, gene sets separating good and poor outcome could be found for all end-points. However, when splitting tumors into training and validation groups, no robust classifiers could be found. Also previously published signatures with prognostic value have been tested. Conclusion. Gene sets can be found with predictive potential for locoregional control after combined radiation and chemotherapy in HNSCC. How treatment-specific these gene sets are needs further study.

2008-02-19 | E-NCMF-8 | biostudies-arrayexpress

Transcription profiling of spontaneous and transplanted topotecan-resistant BRCA1;P53-deficient mouse mammary tumors

Project description:Gene expression profiles of "spontaneous" and transplanted topotecan-resistant BRCA1;P53-deficient mammary tumors and their matched untreated controls

2010-01-05 | E-NCMF-28 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data