Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Brca1- and p53-deficient mouse mammary tumors to treatment with doxorubicin, docetaxel or cisplatin

ABSTRACT: We have studied in vivo responses of spontaneous Brca1- and p53-deficient mouse mammary tumors to treatment with doxorubicin, docetaxel or cisplatin.

ORGANISM(S): Mus musculus

SUBMITTER: Cor Lieftink 

PROVIDER: E-NCMF-5 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer.

Rottenberg Sven S   Nygren Anders O H AO   Pajic Marina M   van Leeuwen Fijs W B FW   van der Heijden Ingrid I   van de Wetering Koen K   Liu Xiaoling X   de Visser Karin E KE   Gilhuijs Kenneth G KG   van Tellingen Olaf O   Schouten Jan P JP   Jonkers Jos J   Borst Piet P  

Proceedings of the National Academy of Sciences of the United States of America 20070711 29

We have studied in vivo responses of "spontaneous" Brca1- and p53-deficient mammary tumors arising in conditional mouse mutants to treatment with doxorubicin, docetaxel, or cisplatin. Like human tumors, the response of individual mouse tumors varies, but eventually they all become resistant to the maximum tolerable dose of doxorubicin or docetaxel. The tumors also respond well to cisplatin but do not become resistant, even after multiple treatments in which tumors appear to regrow from a small f  ...[more]

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