Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human dermal endothelial cells treated with 10ng/ml VEGF and 20ng/ml basic Fibroblast Growth Factor (bFGF) for 6h

ABSTRACT: Cells were treated with 10ng/ml VEGF and 20ng/ml basic Fibroblast Growth Factor (bFGF) for 6h at 37°C with 5 % CO2 and 95 % humidity..

ORGANISM(S): Homo sapiens

SUBMITTER: Robert Wagner 

PROVIDER: E-RZPD-14 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcriptional network governing the angiogenic switch in human pancreatic cancer.

Abdollahi Amir A   Schwager Christian C   Kleeff Jörg J   Esposito Irene I   Domhan Sophie S   Peschke Peter P   Hauser Kai K   Hahnfeldt Philip P   Hlatky Lynn L   Debus Jürgen J   Peters Jeffrey M JM   Friess Helmut H   Folkman Judah J   Huber Peter E PE  

Proceedings of the National Academy of Sciences of the United States of America 20070724 31

A shift of the angiogenic balance to the proangiogenic state, termed the "angiogenic switch," is a hallmark of cancer progression. Here we devise a strategy for identifying genetic participants of the angiogenic switch based on inverse regulation of genes in human endothelial cells in response to key endogenous pro- and antiangiogenic proteins. This approach reveals a global network pattern for vascular homeostasis connecting known angiogenesis-related genes with previously unknown signaling com  ...[more]

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