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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human gastric cancers

ABSTRACT: We analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing approximately 30,300 genes. Expression of PLA2G2A, a gene previously implicated as a modifier of the Apc(Min/+) (multiple intestinal neoplasia 1) mutant phenotype in the mouse, was significantly correlated with patient survival. We confirmed this observation in an independent set of patient samples by using quantitative RT-PCR. Beyond its potential diagnostic and prognostic significance, this result suggests the intriguing possibility that the activity of PLA2G2A may suppress progression or metastasis of human gastric cancer.

ORGANISM(S): Homo sapiens

SUBMITTER: Janos Demeter

PROVIDER: E-SMDB-1743 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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PLA2G2A and human gastric cancers

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