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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human follicular lymphoma and normal lymphoid tissue comparisons

ABSTRACT: 20 FL lymph node samples from 16 patients and four normal lymphoid tissues (two tonsil and two spleen) from four different patient. Data can be viewed on the supplemental website at http://genome-www.stanford.edu/rituximab/.

ORGANISM(S): Homo sapiens

SUBMITTER: Janos Demeter

PROVIDER: E-SMDB-1845 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Variation in gene expression patterns in follicular lymphoma and the response to rituximab.

Bohen Sean P SP Troyanskaya Olga G OG Alter Orly O Warnke Roger R Botstein David D Brown Patrick O PO Levy Ronald R

Proceedings of the National Academy of Sciences of the United States of America 20030205 4

Analysis of the patterns of gene expression in follicular lymphomas from 24 patients suggested that two groups of tumors might be distinguished. All patients, whose biopsies were obtained before any treatment, were treated with rituximab, a monoclonal antibody directed against the B cell antigen, CD20. Gene expression patterns in the tumors that subsequently failed to respond to rituximab appeared more similar to those of normal lymphoid tissues than to gene expression patterns of tumors from ri ...[more]

PMID: 12571354

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Follicular lymphoma and normal lymphoid tissue comparisons

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Variation in gene expression patterns in follicular lymphoma and the response to rituximab

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Project description:Despite recent advances in the characterization of stromal cell origin, heterogeneity, and function in mice, little is known in human. Follicular lymphoma (FL) is the most frequent indolent lymphoma. It corresponds to the accumulation of germinal center B-cell clones within lymph nodes. FL B cells interact with a reprogrammed immune and stromal cells that provide crucial contributions to the licensing of tumor growth and immune evasion. Most of transcriptomics approaches in human was performed on cultured, and amplified stromal cells modifying their phenotype and function. We purified native stromal cells from LN FL patients, healthy tonsil, and healthy bone marrow. Gene expression profiling based on three lymphoid stromal cell types provides new insights on the characterization of those cells in human and highlight new signalling pathways involved in the crosstalk between stromal cells and tumoral FL B cells.

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| 2010075 | ecrin-mdr-crc