Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse HSF1+/+ and HSF1-/- fibroblasts heat shock time series


ABSTRACT: Mouse HSF1+/+ and HSF1-/- Fibroblasts Heat Shock Time Courses Scanned on Scanner 7 (Axon 4000B)

ORGANISM(S): Mus musculus

SUBMITTER: John Murray 

PROVIDER: E-SMDB-1853 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The role of heat shock transcription factor 1 in the genome-wide regulation of the mammalian heat shock response.

Trinklein Nathan D ND   Murray John I JI   Hartman Sara J SJ   Botstein David D   Myers Richard M RM  

Molecular biology of the cell 20031210 3


Previous work has implicated heat shock transcription factor 1 (HSF1) as the primary transcription factor responsible for the transcriptional response to heat stress in mammalian cells. We characterized the heat shock response of mammalian cells by measuring changes in transcript levels and assaying binding of HSF1 to promoter regions for candidate heat shock genes chosen by a combination of genome-wide computational and experimental methods. We found that many heat-inducible genes have HSF1 bin  ...[more]

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