Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Transcription profiling of H. pylori stationary (Stat Chelate and Stat.iron.survival)and exponential (Log Chelate and Log.iron.survival) subjected to chelation using DPP

ABSTRACT: This data set was used to determine genes that are regulated by iron availability and to access the growth phase dependence on that regulation. Stationary (Stat Chelate and Stat.iron.survival)and exponential (Log Chelate and Log.iron.survival)were subjected to chelation using DPP. Growth status of the cultures was confirmed by determing the correlation coefficient of the Stat chelate T=0/control and Log Chelate T=0/control vs data generated in the TC Motility series. Arrays used for iron addback experiments are listed as FeAddBack-1-time or FeAddBack-2-time.

ORGANISM(S): Helicobacter pylori

SUBMITTER: Janos Demeter 

PROVIDER: E-SMDB-2267 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Growth phase-dependent response of Helicobacter pylori to iron starvation.

Merrell D Scott DS   Thompson Lucinda J LJ   Kim Charles C CC   Mitchell Hazel H   Tompkins Lucy S LS   Lee Adrian A   Falkow Stanley S  

Infection and immunity 20031101 11

Iron is an essential nutrient that is often found in extremely limited available quantities within eukaryotic hosts. Because of this, many pathogenic bacteria have developed regulated networks of genes important for iron uptake and storage. In addition, it has been shown that many bacteria use available iron concentrations as a signal to regulate virulence gene expression. We have utilized DNA microarray technology to identify genes of the human pathogen Helicobacter pylori that are differential  ...[more]

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