Transcription profiling of S. typhimurium treated with bile
Ontology highlight
ABSTRACT:
ORGANISM(S): Salmonella enterica serovar Typhimurium
SUBMITTER: Janos Demeter
PROVIDER: E-SMDB-2621 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Bile-salt-mediated induction of antimicrobial and bile resistance in Salmonella typhimurium.
Prouty A M AM Brodsky I E IE Falkow S S Gunn J S JS
Microbiology (Reading, England) 20040401 Pt 4
By DNA microarray, the Salmonella typhimurium marRAB operon was identified as being bile-activated. Transcriptional assays confirm that marRAB is activated in the presence of bile and that this response is concentration-dependent. The bile salt deoxycholate is alone able to activate transcription, while there was no response in the presence of other bile salts tested or a non-ionic detergent. Deoxycholate is able to interact with MarR and interfere with its ability to bind to the mar operator. I ...[more]
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