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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of breast cancer tumors of ductal and classical lobular types

ABSTRACT: Breast cancer tumors: of ductal (D) and classical lobular (L) type. Experiment "BC2_Jeffrey_minus_G50_1" was denoted as BC-D-002.

ORGANISM(S): Homo sapiens

SUBMITTER: Janos Demeter

PROVIDER: E-SMDB-3963 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Disease-specific genomic analysis: identifying the signature of pathologic biology.

Nicolau Monica M Tibshirani Robert R Børresen-Dale Anne-Lise AL Jeffrey Stefanie S SS

Bioinformatics (Oxford, England) 20070203 8

<h4>Motivation</h4>Genomic high-throughput technology generates massive data, providing opportunities to understand countless facets of the functioning genome. It also raises profound issues in identifying data relevant to the biology being studied.<h4>Results</h4>We introduce a method for the analysis of pathologic biology that unravels the disease characteristics of high dimensional data. The method, disease-specific genomic analysis (DSGA), is intended to precede standard techniques like clus ...[more]

PMID: 17277331

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Transcription profiling of breast cancer tumors of ductal and lobular types

Project description:Breast cancer tumors of ductal (D) and lobular (L) type. Not all lobular tumors are "classical lobular" tumors. Experiment "BC2_Jeffrey_minus_G50_1" was denoted as BC-D-002.

2007-03-27 | E-SMDB-3962 | biostudies-arrayexpress

Transcription profiling of human lobular and ductal invasive carcinomas vs normal breast tissue from the same patient to identify gene expression profiles of ductal and lobular carcinomas in relation to normal ductal and lobular cells

Project description:The aim of our study was to identify gene expression profiles of ductal and lobular carcinomas in relation to normal ductal and lobular cells. We examined ten mastectomy specimens from postmenopausal breast cancer patients. Ductal and lobular tumor and normal cells were microdissected from cryosections. Fifty nanograms of total RNA were amplified and labeled by PCR and in vitro transcription. GCOS pairwise comparison algorithm and rank products have identified multiple genes that are differentially expressed in comparisons between ductal and lobular tumor and normal cell types. The results suggest that these genes are involved in epithelial-mesenchymal transition, TGFbeta and Wnt signaling. These changes are present in both tumor types but appear to be more prominent in lobular carcinomas. Ten surgical specimens obtained by mastectomy from postmenopausal patients with invasive ductal (IDC) and lobular breast (ILC) carcinomas were investigated. Of these, 5 were IDCs and 5 were ILCs. Tumor and normal tissues from the same mammary gland were identified by an experienced pathologist, snap-frozen in liquid nitrogen and stored at -80ÂºC for further analysis. Microdissection, RNA isolation, amplification, labeling and microarray analysis are described in sample definitions. Samples from particular cell types (normal ductal, normal lobular, tumor ductal, tumor lobular - 10, 10, 5, 5 samples, respectively) were considered as biological replicates and were compared in between.

2007-11-01 | E-GEOD-5764 | biostudies-arrayexpress

Analysis of microdissected invasive lobular and ductal breast carcinomas in relation to normal ductal and lobular cells

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Characterisation of gene expression of cancer-associated and normal fibroblasts from lobular and ductal breast cancer patients

Project description:The purpose of this study was to characterise gene expression differences between cultured human cancer-associated fibroblasts and normal fibroblasts from lobular and ductal breast cancer patients.

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Transcription profiling of breast cancer tumors of ductal and classical lobular types

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2015-08-21 | E-GEOD-60601 | biostudies-arrayexpress

Gene expression data from CD14++ CD16- classical monocytes from healthy volunteers and patients with pancreatic ductal adenocarcinoma

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