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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Mistranslation accelerates the adaptation of Candida albicans to Fluconazole

ABSTRACT: The leucine CUG codon was reassigned to serine in the fungal pathogen Candida albicans. To clarify the biological role of this tuneable codon ambiguity on drug resistance, we evolved C. albicans strains that were engineered to mistranslate the CUG codon at constitutively elevated levels, in the presence and absence of the antifungal drug fluconazole. Elevated levels of mistranslation resulted in the rapid acquisition of resistance to fluconazole.

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Candida albicans

SUBMITTER: Tobias Weil

PROVIDER: E-SYBR-13 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Mistranslation accelerates the evolution of antifungal drug resistance in Candida albicans [CGH]

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Mistranslation accelerates the adaptation of Candida albicans to Fluconazole

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