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Transcription profiling of 23 human thyroid tissues including 11 normal tissue, 4 follicular thyroid adenomas and 8 follicular thyroid carcinomas, in order to identify molecular profile associated with PAX8PPARgamma translocation

ABSTRACT: Study of a series of 23 human thyroid tissues including 11 normal tissue, 4 follicular thyroid adenomas and 8 follicular thyroid carcinomas, in order to identify molecular profile associated with PAX8PPARgamma translocation. The main factor is presence of PAX8PPARgamma translocation. Other clinical factors are also described for each sample. (see supplementary Tables). The reference used is a pool of equal quantities of mRNA from each of the 23 samples studied.

ORGANISM(S): Homo sapiens

SUBMITTER: Vladimir Lazar

PROVIDER: E-TABM-11 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Follicular thyroid tumors with the PAX8-PPARgamma1 rearrangement display characteristic genetic alterations.

Lacroix Ludovic L Lazar Vladimir V Michiels Stefan S Ripoche Hugues H Dessen Philippe P Talbot Monique M Caillou Bernard B Levillain Jean-Pierre JP Schlumberger Martin M Bidart Jean-Michel JM

The American journal of pathology 20050701 1

Follicular thyroid carcinomas (FTC) arise through oncogenic pathways distinct from those involved in the papillary histotype. Recently, a t(2;3)(q13;p25) rearrangement, which juxtaposes the thyroid transcription factor PAX8 to the peroxisome proliferator-activated receptor (PPAR) gamma1, was described in FTCs. In this report, we describe gene expression in 11 normal tissues, 4 adenomas, and 8 FTCs, with or without the PAX8-PPARgamma1 translocation, using custom 60-mer oligonucleotide microarrays ...[more]

PMID: 15972966

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