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Unknown,Transcriptomics,Genomics,Proteomics

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Phospholipase PLA2G7 is a drug target and a potent biomarker in prostate cancer

ABSTRACT: Effects of siRNA treatment on gene expression in VCaP prostate cancer cell line

ORGANISM(S): Homo sapiens

SUBMITTER: Paula Vainio

PROVIDER: E-TABM-1172 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins.

Vainio Paula P Lehtinen Laura L Mirtti Tuomas T Hilvo Mika M Seppänen-Laakso Tuulikki T Virtanen Johannes J Sankila Anna A Nordling Stig S Lundin Johan J Rannikko Antti A Orešič Matej M Kallioniemi Olli O Iljin Kristiina K

Oncotarget 20111201 12

Prostate cancer is the second leading cause of cancer mortality in men in developed countries. Due to the heterogeneous nature of the disease, design of novel personalized treatments is required to achieve efficient therapeutic responses. We have recently identified phospholipase 2 group VII (PLA2G7) as a potential drug target especially in ERG oncogene positive prostate cancers. Here, the expression profile of PLA2G7 was studied in 1137 prostate cancer and 409 adjacent non-malignant prostate ti ...[more]

PMID: 22202492

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