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Unknown,Transcriptomics,Genomics,Proteomics

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Neural embryonic stem cell (ESTn) test dose-responses of Valproic Acid, Cyproconazole and Hexaconazole in the neural embryonic stem cell test.

ABSTRACT: Effects of Valproic Acid, Cyproconazole and Hexaconazole on stem cell neural development.

ORGANISM(S): Mus musculus

SUBMITTER: Jeroen Pennings

PROVIDER: E-TABM-1205 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Complementary detection of embryotoxic properties of substances in the neural and cardiac embryonic stem cell tests.

Theunissen Peter T PT Pennings Jeroen L A JL van Dartel Dorien A M DA Robinson Joshua F JF Kleinjans Jos C S JC Piersma Aldert H AH

Toxicological sciences : an official journal of the Society of Toxicology 20121213 1

In developmental toxicity testing, in vitro screening assays are highly needed to increase efficiency and to reduce animal use. A promising in vitro assay is the cardiac embryonic stem cell test (ESTc), in which the effect of developmental toxicants on cardiomyocyte differentiation is assessed. Recently, we developed a neural differentiation variant of the stem cell test (neural embryonic stem cell test [ESTn]). In both of these models, we have previously performed a series of transcriptomic stu ...[more]

PMID: 23243006

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