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Gene expression signature associated with ASXL1 mutations in cytogenetically normal acute myeloid leukemia (CN-AML)

ABSTRACT: We studied gene expression profiles from 65 patients with CN-AML, who all had wild-type NPM1 and no FLT3-ITD. We identified an ASXL1 mutation-associated gene expression signature by comparing 26 ASXL1-mutated and 39 ASXL1-wild type patients. Only NPM1 wild type/FLT3-ITD-negative patients were included in this analysis to avoid potential confounding due to the effects of these two mutations on gene expression.

ORGANISM(S): Homo sapiens

SUBMITTER: Guido Marcucci

PROVIDER: E-TABM-1208 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category.

Metzeler Klaus H KH Becker Heiko H Maharry Kati K Radmacher Michael D MD Kohlschmidt Jessica J Mrózek Krzysztof K Nicolet Deedra D Whitman Susan P SP Wu Yue-Zhong YZ Schwind Sebastian S Powell Bayard L BL Carter Thomas H TH Wetzler Meir M Moore Joseph O JO Kolitz Jonathan E JE Baer Maria R MR Carroll Andrew J AJ Larson Richard A RA Caligiuri Michael A MA Marcucci Guido G Bloomfield Clara D CD

Blood 20111026 26

The associations of mutations in the enhancer of trithorax and polycomb family gene ASXL1 with pretreatment patient characteristics, outcomes, and gene-/microRNA-expression profiles in primary cytogenetically normal acute myeloid leukemia (CN-AML) are unknown. We analyzed 423 adult patients for ASXL1 mutations, other prognostic gene mutations, and gene-/microRNA-expression profiles. ASXL1 mutations were 5 times more common in older (≥ 60 years) patients (16.2%) than those younger than 60 years ( ...[more]

PMID: 22031865

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2010-07-23 | E-TABM-1029 | biostudies-arrayexpress

identifying mRNA expression regulated by FLT3/ITD and Cxcl12

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