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Slx5_Slx8_Genome_Stability

ABSTRACT: This hybset contains the expression profiles of the following yeast deletion mutants: cdc26, ctf4, ctf18, rad18, rad50, rad51, rmi1, sgs1, slx5, slx8, csm1, mcm21, ctf19, ybp2, cin8, rts1, pph22.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Marian Groot Koerkamp

PROVIDER: E-TABM-1221 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Centromere binding and a conserved role in chromosome stability for SUMO-dependent ubiquitin ligases.

van de Pasch Loes A L LA Miles Antony J AJ Nijenhuis Wilco W Brabers Nathalie A C H NA van Leenen Dik D Lijnzaad Philip P Brown Markus K MK Ouellet Jimmy J Barral Yves Y Kops Geert J P L GJ Holstege Frank C P FC

PloS one 20130613 6

The Saccharomyces cerevisiae Slx5/8 complex is the founding member of a recently defined class of SUMO-targeted ubiquitin ligases (STUbLs). Slx5/8 has been implicated in genome stability and transcription, but the precise contribution is unclear. To characterise Slx5/8 function, we determined genome-wide changes in gene expression upon loss of either subunit. The majority of mRNA changes are part of a general stress response, also exhibited by mutants of other genome integrity pathways and there ...[more]

PMID: 23785440

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