Unknown,Transcriptomics,Genomics,Proteomics

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Comparative genomic hybridization of human breast tumor samples


ABSTRACT: Application of array comparative genomic hybridization (CGH) to the analysis of breast tumors

ORGANISM(S): Homo sapiens

SUBMITTER: Taku Tokuyasu 

PROVIDER: E-TABM-170 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


<h4>Background</h4>Genomic DNA copy number aberrations are frequent in solid tumors, although the underlying causes of chromosomal instability in tumors remain obscure. Genes likely to have genomic instability phenotypes when mutated (e.g. those involved in mitosis, replication, repair, and telomeres) are rarely mutated in chromosomally unstable sporadic tumors, even though such mutations are associated with some heritable cancer prone syndromes.<h4>Methods</h4>We applied array comparative genom  ...[more]

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