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Transcription profiling of aging in the primate brain

ABSTRACT: An experiment was performed to study effects of aging on gene expression in chimpanzee brains.

ORGANISM(S): Pan troglodytes

SUBMITTER: Joshua Plotkin

PROVIDER: E-TABM-25 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Aging and gene expression in the primate brain.

Fraser Hunter B HB Khaitovich Philipp P Plotkin Joshua B JB Pääbo Svante S Eisen Michael B MB

PLoS biology 20050802 9

It is well established that gene expression levels in many organisms change during the aging process, and the advent of DNA microarrays has allowed genome-wide patterns of transcriptional changes associated with aging to be studied in both model organisms and various human tissues. Understanding the effects of aging on gene expression in the human brain is of particular interest, because of its relation to both normal and pathological neurodegeneration. Here we show that human cerebral cortex, h ...[more]

PMID: 16048372

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