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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of rat peripheral blood leukocytes treated with the estrogen receptor agonists estradiol, PPT and DPN to investigates the functional roles of estrogen receptor alpha and beta

ABSTRACT: This experiment investigates the functional roles of estrogen receptor alpha and beta in peripheral blood leukocytes by using selective estrogen receptor agonists. The agonists that are used are estradiol (E2), the selective ER-alpha agonist PPT (4,4',4''-(4-Propyl-[1H]-pyrazole-1,3,5-triyl)trisphenol) and the selective ER-beta agonist DPN (2,3-bis(4-hydroxyphenyl)-propionitrile).

ORGANISM(S): Rattus norvegicus

SUBMITTER: Valtteri Wirta

PROVIDER: E-TABM-269 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Studies on estrogen receptor (ER) alpha and beta responses on gene regulation in peripheral blood leukocytes in vivo using selective ER agonists.

Stygar Denis D Masironi Britt B Eriksson Håkan H Sahlin Lena L

The Journal of endocrinology 20070701 1

Major reproductive events such as menstruation, ovulation, implantation, and cervical ripening are characterized by an increased number of invading leukocytes in the tissues. Sex steroid hormones, particularly estrogens, play an important role in these dynamic changes in the female reproductive tract. Estrogens have also been implicated in the pathogenesis of many common pathological conditions associated with leukocyte infiltration and immunological dysfunction, such as auto-immune diseases and ...[more]

PMID: 17592025

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