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Comparative genomic hybridization to investigate contingency genes in clinical isolates of Streptococcus pneumoniae

ABSTRACT: Identification of genetic differences and similarities between clinical isolates of s.pneumoniae of the same sequence type and /or serotype

ORGANISM(S): Streptococcus pneumoniae

SUBMITTER: Christel Blomberg

PROVIDER: E-TABM-320 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Determination of accessory gene patterns predicts the same relatedness among strains of Streptococcus pneumoniae as sequencing of housekeeping genes does and represents a novel approach in molecular epidemiology.

Dagerhamn Jessica J Blomberg Christel C Browall Sarah S Sjöström Karin K Morfeldt Eva E Henriques-Normark Birgitta B

Journal of clinical microbiology 20071226 3

Relatedness between isolates of Streptococcus pneumoniae can be determined from sequences of multiple genes belonging to the core genome (multilocus sequence typing [MLST]), but these do not provide information on gene content that may affect the potential of isolates to cause invasive pneumococcal disease. Gene content data, obtained using microarrays, were gathered for 40 clinical isolates of 12 serotypes belonging to 30 multilocus sequence types. We found that sequence variations in housekeep ...[more]

PMID: 18160453

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