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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of insecticide susceptible and resistant strains of Aedes aegypti to identify detoxification genes

ABSTRACT: Genomic analysis of detoxification genes in the mosquito Aedes aegypti

ORGANISM(S): Aedes aegypti

SUBMITTER:

PROVIDER: E-TABM-414 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genomic analysis of detoxification genes in the mosquito Aedes aegypti.

Strode Clare C Wondji Charles S CS David Jean-Philippe JP Hawkes Nicola J NJ Lumjuan Nongkran N Nelson David R DR Drane David R DR Karunaratne S H P Parakrama SH Hemingway Janet J Black William C WC Ranson Hilary H

Insect biochemistry and molecular biology 20070929 1

Annotation of the recently determined genome sequence of the major dengue vector, Aedes aegypti, reveals an abundance of detoxification genes. Here, we report the presence of 235 members of the cytochrome P450, glutathione transferase and carboxy/cholinesterase families in Ae. aegypti. This gene count represents an increase of 58% and 36% compared with the fruitfly, Drosophila melanogaster, and the malaria mosquito, Anopheles gambiae, respectively. The expansion is not uniform within the gene fa ...[more]

PMID: 18070670

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