Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human patients with diffuse large B-cell lymphoma treated with CHOP or Ritxumab-CHOP

ABSTRACT: A "Cartes d'Identite des Tumeurs" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). 53 samples hybridized on Affymetrix HG-U133A GeneChips arrays, for 53 patients with diffuse large B-cell lymphoma (DLBCL); patients are treated with CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) or Ritxumab (R)-CHOP in the Groupe dB^REtude des Lymphomes de lB^RAdulte (GELA) clinical centers.

ORGANISM(S): Homo sapiens

SUBMITTER: Fabien Petel 

PROVIDER: E-TABM-346 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The expression of 16 genes related to the cell of origin and immune response predicts survival in elderly patients with diffuse large B-cell lymphoma treated with CHOP and rituximab.

Jais J-P JP   Haioun C C   Molina T J TJ   Rickman D S DS   de Reynies A A   Berger F F   Gisselbrecht C C   Brière J J   Reyes F F   Gaulard P P   Feugier P P   Labouyrie E E   Tilly H H   Bastard C C   Coiffier B B   Salles G G   Leroy K K  

Leukemia 20080710 10

Gene expression profiles have been associated with clinical outcome in patients with diffuse large B-cell lymphoma (DLBCL) treated with anthracycline-containing chemotherapy. Using Affymetrix HU133A microarrays, we analyzed the lymphoma transcriptional profile of 30 patients treated with CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) and 23 patients treated with rituximab (R)-CHOP in the Groupe d'Etude des Lymphomes de l'Adulte clinical centers. We used this data set to select tra  ...[more]

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