Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Isabelle Lucas
PROVIDER: E-TABM-347 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Jiang Yanwen Y Lucas Isabelle I Young David J DJ Davis Elizabeth M EM Karrison Theodore T Rest Joshua S JS Le Beau Michelle M MM
Human molecular genetics 20090828 23
Common fragile sites (CFSs) represent large, highly unstable regions of the human genome. CFS sequences are sensitive to perturbation of replication; however, the molecular basis for the instability at CFSs is poorly understood. We hypothesized that a unique epigenetic pattern may underlie the unusual sensitivity of CFSs to replication interference. To examine this hypothesis, we analyzed chromatin modification patterns within the six human CFSs with the highest levels of breakage, and their sur ...[more]