Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profling of human neuroblastoma samples to construct, validate and evalute a gene expression based classification of outcome of treatment


ABSTRACT: This set of 320 profiles was utilized to construct, validate and evaluate a gene-expression based classifier of outcome of neuroblastoma patients

ORGANISM(S): Homo sapiens

SUBMITTER: Yvonne Kahlert 

PROVIDER: E-TABM-38 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Customized oligonucleotide microarray gene expression-based classification of neuroblastoma patients outperforms current clinical risk stratification.

Oberthuer André A   Berthold Frank F   Warnat Patrick P   Hero Barbara B   Kahlert Yvonne Y   Spitz Rüdiger R   Ernestus Karen K   König Rainer R   Haas Stefan S   Eils Roland R   Schwab Manfred M   Brors Benedikt B   Westermann Frank F   Fischer Matthias M  

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20061101 31


<h4>Purpose</h4>To develop a gene expression-based classifier for neuroblastoma patients that reliably predicts courses of the disease.<h4>Patients and methods</h4>Two hundred fifty-one neuroblastoma specimens were analyzed using a customized oligonucleotide microarray comprising 10,163 probes for transcripts with differential expression in clinical subgroups of the disease. Subsequently, the prediction analysis for microarrays (PAM) was applied to a first set of patients with maximally divergen  ...[more]

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