Project description:This work aimed at analysing the transcriptome response of S. cerevisiae strains, wild type or deleted for transcription factor encoding genes involved in stress response, to selenite (1mM), inoculated for different time periods.
Project description:This work aimed at analysing the transcriptome response of C. albicans wild type strain to three different doses of malachite green, inoculated for four different time periods.
Project description:This work aimed at analysing the transcriptome response of S. cerevisiae and C. albicans strains, wild type or deleted for transcription factor encoding genes involved in pleiotropic drug resistance, to three different doses of progesterone, inoculated for three different time periods.
Project description:Transcriptome analyses of thermosensitive exosome mutants from permissive temperature to various time exposure to restrictive temperature.
Project description:Mating is a complex process that causes many behavioral and physiological changes, but the factors triggering these changes and the underlying molecular processes are not well characterized. Honey bee queens provide a convenient system for dissecting these factors (e.g., physical manipulation, insemination volume, insemination substance) via instrumental insemination. We examined the effects of carbon dioxide (CO2), a commonly used anesthetic in instrumental insemination that causes changes similar to those observed after mating, and physical manipulation, which presumably mimics the act of copulation, on the brain transcriptional changes in honey bee queens. We found significant gene overlap between our study and previous mating studies in honey bee queens and Drosophila. This suggests that molecular pathways regulating the mating process are conserved across different mating regimes of honey bees as well as across insect orders.
Project description:RNA-seq analysis to assess the effect of different drugs (34503, 36009, 34503, 36018, Moxi) on Mycobacterium tuberculosis compared to untreated control cells (DMSO).
Project description:To determine the impact of RNA quality on the expression profiles generated by an in vitro HepG2 Cell line model to challenge with a panel of Pharmaceutical compounds.
Project description:To examine the impact of RNA integrity on the expression profile of model HepG2 cell system in response to challenge by a pharmaceutically active compound