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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse naive and memory CD8+ T cells

ABSTRACT: This experiment compared the expression of mRNAs and noncoding RNAs between naive and memory CD8+ T cells, with the primary aim of identifying noncoding RNAs that were dynamically regulated during T cell differentiation.

ORGANISM(S): Mus musculus

SUBMITTER: Marcel Dinger

PROVIDER: E-TABM-492 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genome-wide identification of long noncoding RNAs in CD8+ T cells.

Pang Ken C KC Dinger Marcel E ME Mercer Tim R TR Malquori Lorenzo L Grimmond Sean M SM Chen Weisan W Mattick John S JS

Journal of immunology (Baltimore, Md. : 1950) 20090601 12

Previous research into the molecular mechanisms that underlie Ag-specific CD8(+) T cell differentiation and function has largely focused on the role of proteins. However, it is now apparent that the mammalian genome expresses large numbers of long (>200 nt) nonprotein-coding RNAs (ncRNAs), and there is increasing evidence that these RNAs have important regulatory functions, particularly in the regulation of epigenetic processes underpinning cell differentiation. In this study, we show that CD8(+ ...[more]

PMID: 19494298

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